Frequently Asked Questions about Methyl 4-Bromobutyrate

Basic Information:

Aliases: 4-Bromobutyric Acid Methyl Ester, 4-Bromo-n-butyrate Methyl Ester

CAS No: 4897-84-1

Molecular Formula: C5H9BrO2

Molecular Weight: 181.03

Physical State: Colorless to pale yellow transparent liquid

Melting Point: 175-190°C

Boiling Point: 186-187°C

Density: 1.434 g/cm³

Uses: It can be used to prepare cyclopropylmethylcyanide derivatives, which are important high-activity compounds.

1. What is Methyl 4-Bromobutyrate?

Methyl 4-Bromobutyrate (CAS No: 4897-84-1) is an organic compound with the molecular formula C₅H₉BrO₂, belonging to the class of bromo esters. It is commonly used in organic synthesis, pharmaceutical intermediates, and chemical research. Methyl 4-Bromobutyrate has excellent chemical activity and is an ideal intermediate for many chemical reactions.

2. What are the main applications of Methyl 4-bromobutyrate?

Methyl 4-Bromobutyrate is primarily used for:

Organic synthesis: As an intermediate in the synthesis of other chemicals.

Pharmaceutical industry: For the synthesis of drugs and other active compounds.

Agrochemical chemistry: As a raw material for synthesizing certain agrochemical products.

In addition, Methyl 4-Bromobutyrate is widely used in chemical research and industrial production, particularly in bromination and esterification reactions.

3. What are the physical properties of Methyl 4-bromobutyrate?

The physical properties of Methyl 4-Bromobutyrate are as follows:

Molecular formula: C₅H₉BrO₂

Molecular weight: 169.03 g/mol

Appearance: Colorless to pale yellow liquid

Density: 1.389 g/cm³ (20°C)

Melting point: Low solidification temperature, usually handled at room temperature

Boiling point: About 210°C

Solubility: Soluble in organic solvents such as ethanol and ether but poorly soluble in water.

4. What are the synthesis methods of Methyl 4-Bromobutyrate?

The synthesis methods of Methyl 4-bromobutyrate mainly include:

Bromination reaction: Reacting butyric acid with bromine gas to produce 4-bromobutyric acid, which is then reacted with methanol to produce Methyl 4-Bromobutyrate.

Esterification reaction: Reacting 4-bromobutyric acid with methanol to produce Methyl 4-Bromobutyrate.

These synthesis methods are commonly used in laboratory and industrial settings to produce high-purity Methyl 4-bromobutyrate.

5. What are the storage conditions for Methyl 4-Bromobutyrate?

Methyl 4-Bromobutyrate should be stored in a cool, dry, and well-ventilated place, avoiding direct sunlight. As a volatile chemical, it should be sealed in its original container. It is recommended to avoid contact with oxidizers, strong acids, or strong bases to reduce the risk of reactions.

6. How safe is Methyl 4-Bromobutyrate?

Methyl 4-Bromobutyrate is a chemical with certain toxicity. The following safety precautions should be observed:

Avoid inhalation: Wear appropriate protective equipment, such as masks or respirators, to avoid inhaling vapors or aerosols.

Avoid contact with skin and eyes: Wear protective gloves and goggles to avoid direct contact with skin and eyes.

Storage and disposal: Follow relevant chemical safety regulations during storage and disposal to avoid leaks and environmental contamination.

7. How to test the purity of Methyl 4-bromobutyrate?

The purity of Methyl 4-Bromobutyrate can be tested using the following methods:

Gas Chromatography (GC): Separate Methyl 4-Bromobutyrate through a chromatographic column for quantitative purity analysis.

High-Performance Liquid Chromatography (HPLC): Suitable for purity analysis in complex solvent systems.

Nuclear Magnetic Resonance (NMR): Used to confirm molecular structure and analyze purity.

Fourier Transform Infrared Spectroscopy (FTIR): Analyze functional group characteristic absorption peaks to confirm compound purity.

8. What is the reactivity of Methyl 4-Bromobutyrate with other compounds?

Methyl 4-Bromobutyrate has high chemical reactivity, especially in esterification, bromination, and reduction reactions. It reacts with reducing agents, alkaline substances, and nucleophilic reagents to produce various derivatives. Additionally, due to its bromo group structure, Methyl 4-Bromobutyrate is commonly used as a bromine source in chemical synthesis.

9. Who are the main manufacturers of Methyl 4-bromobutyrate?

The main manufacturers of Methyl 4-Bromobutyrate are typically chemical manufacturers specializing in organic synthesis intermediates. Producers are widely distributed globally, particularly in China, Europe, and the United States. When purchasing, ensure the supplier has relevant production qualifications and quality control systems.

10. What is the market price of Methyl 4-Bromobutyrate?

The market price of Methyl 4-Bromobutyrate varies depending on supply and demand, production scale, and purity. Generally, bulk purchases may offer discounts. It is recommended to contact multiple suppliers and request quotes to get the most competitive price.