Basic Information:
Aliases: 4-Bromobutyric Acid Methyl Ester, 4-Bromo-n-butyrate Methyl Ester
CAS No: 4897-84-1
Molecular Formula: C5H9BrO2
Molecular Weight: 181.03
Physical State: Colorless to pale yellow transparent liquid
Melting Point: 175-190°C
Boiling Point: 186-187°C
Density: 1.434 g/cm³
Uses: It can be used to prepare cyclopropylmethylcyanide derivatives, which are important high-activity compounds.
4-Bromobutyric Acid Methyl Ester (CAS No: 4897-84-1) is an important organic bromine compound widely used in chemical synthesis, particularly in the production of pharmaceuticals, pesticides, and other fine chemical products. Its chemical formula is C5H9BrO2, with a molecular weight of 181.03. It typically appears as a colorless or pale yellow liquid. The presence of a reactive bromine atom in its structure gives the compound high chemical reactivity, making it useful as an intermediate in various reactions.
Synthesis Method
The synthesis of 4-Bromoaniline acid methyl ester typically involves an esterification reaction between 4-bromobutyric acid and methanol. Under acidic catalytic conditions, 4-bromobutyric acid reacts with methanol to form 4-Bromobutyric acid methyl ester. Common catalysts used in this reaction include concentrated sulfuric acid or other acidic catalysts. The reaction is carried out under mild conditions, resulting in high reaction efficiency, making it suitable for large-scale industrial production.
Applications
Pharmaceutical Intermediates
4-Bromobutyric acid methyl ester is an important intermediate for synthesizing various pharmaceutical compounds, especially in the production of antibiotics, antiviral drugs, and other therapeutic agents.
Pesticide Synthesis
In pesticide synthesis, 4-bromobutyric acid methyl ester is used as an important intermediate in the manufacture of herbicides, insecticides, and other agricultural chemicals.
Fragrance and Flavor Industry
4-Bromobutyric acid methyl ester can be used in the synthesis of fragrances and flavor compounds, playing a key role in the production of specific aroma molecules.
Fine Chemicals
Beyond the applications mentioned above, 4-Bromobutyric acid methyl ester is also used as an intermediate in the production of fine chemicals, including polymers, coatings, dyes, and other specialty products.
Physical and Chemical Properties
4-bromobutyric acid methyl ester is a polar compound. Its ester structure, containing a reactive bromine atom, makes it highly reactive in chemical reactions. It can undergo nucleophilic substitution reactions, ester exchange reactions, and other organic reactions.
Safety and Storage
4-Bromobutyric acid methyl ester is chemically stable, but appropriate safety precautions should still be taken during handling. It should be avoided from direct contact with skin and eyes, and protective equipment such as gloves and goggles should be worn. Additionally, it should be stored in a cool, dry place, away from moisture and high temperatures to prevent degradation or reaction.
Conclusion
4-Bromobutyric acid methyl ester is an important brominated ester compound, widely used in the synthesis of pharmaceuticals, agriculture chemicals, fragrances, and fine chemicals. It not only holds significant value in academic research but also plays a key role in industrial production. With the advancement of chemical synthesis technologies, the application prospects for 4-bromobutyric acid methyl ester are broad, especially with the promotion of environmentally friendly and efficient synthesis processes, leading to a growing market demand.